Table 3.
Comparisons of Dissolution Profile of Metformin Hydrochloride 500 mg Tablets Included in the Study by Model Independent Parameters, Jimma Town, 2019 (n=3)
Brands code | Model Independent Approach | Dissolution Efficiency (%) | Difference of Dissolution Efficiency (Innovator-Tested Brands) | MDT | p-value | |
---|---|---|---|---|---|---|
f1 | f2 | |||||
MT001 | 7.80 | 60.88 | 63.60 | 5.42 | 15.13 | 0.89 |
MT002 | 8.35 | 69.70 | 63.70 | 5.32 | 12.95 | |
MT003 | 8.32 | 69.26 | 54.59 | 14.53 | 18.82 | |
MT004 | 9.88 | 97.67 | 53.30 | 15.72 | 17.84 | |
MT005 | 2.08 | 4.33 | 72.01 | −2.99 | 11.11 | |
MT006 | 6.14 | 37.67 | 74.99 | −5.97 | 7.21 | |
MT007 | 8.06 | 65.00 | 66.79 | 2.23 | 11.75 | |
MT008a | – | – | 69.02 | – | 12.07 |
Note:aComparator.
Abbreviations: MDT, mean dissolution time; f1, difference factor; f2, similarity factor.