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. 2021 Aug 5;14:3499–3506. doi: 10.2147/DMSO.S316187

Table 3.

Comparisons of Dissolution Profile of Metformin Hydrochloride 500 mg Tablets Included in the Study by Model Independent Parameters, Jimma Town, 2019 (n=3)

Brands code Model Independent Approach Dissolution Efficiency (%) Difference of Dissolution Efficiency (Innovator-Tested Brands) MDT p-value
f1 f2
MT001 7.80 60.88 63.60 5.42 15.13 0.89
MT002 8.35 69.70 63.70 5.32 12.95
MT003 8.32 69.26 54.59 14.53 18.82
MT004 9.88 97.67 53.30 15.72 17.84
MT005 2.08 4.33 72.01 −2.99 11.11
MT006 6.14 37.67 74.99 −5.97 7.21
MT007 8.06 65.00 66.79 2.23 11.75
MT008a 69.02 12.07

Note:aComparator.

Abbreviations: MDT, mean dissolution time; f1, difference factor; f2, similarity factor.