TABLE 1.
Clinical Data of Patients With Coronavirus Disease 2019
| Clinical Data | Total, n = 86 | Mild, n = 44 | Severe, n = 42 | p (Mild vs Severe) |
|---|---|---|---|---|
| Age (yr) | 61 (48–73) | 59 (46–69) | 67 (52–75) | 0.04 |
| Body mass index (kg/m2) | 25 (23–29) | 25 (23–29) | 25 (23–30) | 0.87 |
| Time from symptoms to hospital (d) | 7 (4–11) | 10 (5–14) | 5 (3–8) | 0.02 |
| Time from symptoms to blood sample (d) | 1 (0–2) | 0.5 (0–1) | 1 (0–2.5) | 0.012 |
| Oxygen saturation: Fio2 ratio | 438 (378–462) | 448 (424–462) | 395 (157–452) | < 0.001 |
| Respiratory rate (breaths/min) | 26 (20–32) | 24 (19–31) | 28 (21–36) | 0.06 |
| Temperature (°C) | 37.5 (36.9–38.4) | 37.2 (36.8–38.1) | 37.7 (37.0–38.8) | 0.22 |
| Threshold cycle value | 37 (32–40) | 38 (35–40) | 34 (28–39) | 0.01 |
| Male (%) | 55 (64) | 24 (56) | 31 (74) | 0.08 |
| Diabetes mellitus (%) | 18 (21) | 9 (21) | 9 (21) | 0.91 |
| Hypertension (%) | 30 (35) | 15 (34) | 15 (38) | 0.70 |
| Smoker (%) | 7 (8) | 5 (11) | 2 (5) | 0.26 |
| Creatinine (micromol/L) | 88 (68–114) | 81 (62–100) | 94 (73–140) | 0.02 |
| C-reactive protein (mg/L) | 114 (52–197) | 78 (32–121) | 180 (106–266) | < 0.001 |
| Albumin (g/L) | 39 (33–41) | 40 (35–42) | 37 (33–40) | 0.04 |
| Bilirubin (micromol/L) | 10 (7–13) | 10 (7–12) | 10 (8–13) | 0.48 |
| Hemoglobin (g/L) | 129 (113–140) | 126 (113–141) | 132 (114–139) | 0.89 |
| Lymphocyte count (109/mL) | 0.93 (0.62–1.36) | 1.14 (0.68–1.52) | 0.75 (0.53–1.16) | 0.04 |
| Neutrophil count (109/mL) | 6.42 (4.40–9.08) | 5.28 (4.11–7.88) | 7.18 (5.56–9.58) | 0.03 |
| Platelet count (109/mL) | 238 (164–290) | 245 (174–298) | 232 (142–288) | 0.33 |
| Steroid use (%) | 7 (8) | 1 (2) | 6 (14) | 0.05 |
| Antiviral drug use (%) | 2 (2) | 0 (0) | 2 (5) | 0.14 |
| Continuous positive airway pressure (%) | 34 (40) | — | 34 (81) | — |
| Mechanical ventilation (%) | 13 (15) | — | 13 (31) | — |
| Vasopressors (%) | 13 (15) | — | 13 (31) | — |
| Renal replacement therapy (%) | 3 (3) | — | 3 (7) | — |
| Hospital mortality (%) | — | — | 21 (24) | — |
Continuous data are presented as median (interquartile range). Mann-Whitney U test and χ2 used to assess differences between patients with mild disease and patients with severe disease or who subsequently died. Dashes indicate not applicable.