Table 2.
The Association Between Migraine and Comorbidities and the Overall Positive IgG Concentration Before and After Adjusting for the Inflammatory Cytokines
| Migraine and Comorbidities | Coefficient (95% CI)a | |||
|---|---|---|---|---|
| Not Adjusting for IL-6, IL-10, and TNF-α | p value | Adjusting for IL-6, IL-10, and TNF-α | p value | |
| Time elapsed since diagnosis (months) | 0.58 (−0.94, 2.09) | 0.45 | 0.36 (−2.26, 2.99) | 0.78 |
| MIDAS | 1.31 (0.84, 1.78) | <0.0001 | 0.63(−0.17, 1.42) | 0.12 |
| Days with migraine in past 12 weeks | 0.70 (0.44, 0.96) | <0.0001 | 0.53 (0.14, 0.91) | 0.0083 |
| VAS | 0.002 (−0.019,0.023) | 0.85 | 0.011 (−0.026, 0.048) | 0.55 |
| HIT-6 | 0.084 (−0.011, 0.18) | 0.083 | 0.0049 (−0.16, 0.17) | 0.95 |
| Days with migraine in past 4 weeks | 0.19 (0.099, 0.29) | 0.0001 | 0.15 (0.0074, 0.29) | 0.04 |
| MSQ | 0.18 (−0.020, 0.38) | 0.077 | −0.022 (−0.36, 0.31) | 0.89 |
| GSRS | 0.31 (0.16, 0.47) | 0.0002 | 0.36 (0.11, 0.62) | 0.0053 |
| SDS | 0.17 (−0.00061, 0.34) | 0.051 | 0.16 (−0.13, 0.44) | 0.27 |
| SAS | 0.14 (−0.024, 0.31) | 0.093 | 0.13 (−0.12, 0.38) | 0.32 |
| PSQI | −0.0084 (−0.064, 0.047) | 0.76 | 0.01 (−0.084, 0.10) | 0.83 |
| OR (95% CI)a | ||||
| Not Adjusting for IL-6, IL-10, and TNF-α | p value | Adjusting for IL-6, IL-10, and TNF-α | p value | |
| With aura | 1.003 (0.96, 1.05) | 0.91 | 1.00 (0.93, 1.07) | 0.97 |
| Chronic migraine | 1.08 (1.03, 1.13) | 0.0015 | 1.07 (0.99, 1.16) | 0.099 |
| Depression | 1.03 (0.99, 1.06) | 0.11 | 0.99 (0.93, 1.06) | 0.75 |
| Anxiety | 1.01 (0.98, 1.05) | 0.48 | 0.98 (0.91, 1.06) | 0.59 |
| Poor sleeping | 0.98 (0.95, 1.01) | 0.22 | 1.01 (0.95, 1.07) | 0.84 |
| Dermatosis | 1.01 (0.98, 1.05) | 0.42 | 0.99 (0.94, 1.05) | 0.75 |
Note: aAssociations were all reported as every 10 u/mL increase in the overall positive IgG level.
Abbreviations: MIDAS, Migraine Disability Assessment questionnaire; VAS, Visual Analog Scale; HIT-6, Headache Impact Test-6; MSQ, Migraine-Specific Quality of Life Questionnaire; GSRS, Gastrointestinal Symptom Rating Scale; SDS, Self-Rating Depression Scale; SAS, Self-Rating Anxiety Scale; PSQI, Pittsburgh Sleep Quality Index; IL-6, interleukin-6; IL-10, interleukin-10; TNF-α, tumor necrosis factor-α.