Table.

Comparing Sputnik V with top COVID-19 vaccines (from [56], modified).

	Sputnik V	AZD1222 or Vaxzevria	Ad26.COV2·S or Janssen COVID-19 Vaccine	BNT162b2 or tozinameran or Comirnaty	mRNA-1273 or Moderna COVID-19 vaccine or Spikevax
Type of vaccine	Adenovirus vector (Ad26 priming and Ad5 boost)	Adenovirus vector (nonreplicating chimpanzee adenovirus)	Adenovirus vector (Ad26)	mRNA in lipid nanoparticles	mRNA (part of virus genetic code) in lipid nanoparticles
Efficacy	91.6%	62–90%	66.3%	95%	94.5%
Storage requirement	−18.5 °C (liquid form) 2–8 °C (dry form)	2–8 °C	2–8 °C	−70 °C ± 10 °C	−20 °C ± 5 °C
Number of shots	X2 (3 weeks apart)	X2 (8–12 weeks apart)	X1	X2 (3 weeks apart)	X2 (4 weeks apart)
Cost per dose	$10	$2.15 in the EU; $3–4 in the UK and U.S.; $5.25 in South Africa	$10	$19.50	$25-$37
Efficacy on variants	Unknown. Clinical trials were largely conducted in Russia prior to the emergence of major variants. Some data suggest reduced effect against the Beta and Gamma variants	Little effect against the Beta variant, but appears effective against Alpha and Gamma variants	Effective against the variants, although less so against Beta and Gamma variants	Lab data suggest “quite effective” against Alpha variant as well as Beta and Gamma variants	Lab data suggest “quite effective” against Alpha variant as well as Beta and Gamma variants