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. 2021 Aug 10;36(9):109627. doi: 10.1016/j.celrep.2021.109627

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© 2021 The Author(s)

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Sequence determinants and structural basis of S RBD escape mutants

Limited per-position heatmap (left) and mutations mapped onto the S RBD-ACE2 structural complex (right; PDB: 6M0J). For clarity, only positions with two or more escape mutations are shown with surface colored. (A) nAbs CC12.1, CC12.3, and CC12.13. Boxes indicate escape mutants for two or more nAbs, while triangles indicate an escape mutant identified for just one nAb (top left: CC12.1, bottom right: CC12.3, bottom left: CC12.13); (B) CC6.29 (green) and CC6.31 (orange); and (C) overlay of escape mutants from all nAbs onto the S RBD-ACE2 structural complex.