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. 2021 Aug 6;153(9):e202112875. doi: 10.1085/jgp.202112875

Figure 8.

Figure 8.

The rotameric redistributions of key residues responsible for allosteric coupling upon gate opening in both Shaker and KcsA. (A–D) The rotamer density histograms of key residues for multiple ensembles to represent the different opening degrees from partially to wide open of the intracellular gate. The simulations for Shaker are trajectories 8–23 (Table S1), and the trajectories for KcsA are trajectories 1–10 in a previous study (Li et al., 2018). (E and F) Typical structures to show the process from partially to wide open of the intracellular gate for Shaker (left) and KcsA (right). prob, probability.