Figure 3.

IFNγ licensed allogeneic MSCs mitigate ARS lethality. Balb/c mice were subjected to 4 + 4Gy irradiation. 24 hours later, IFNγ licensed MSCs (20ng/ml for 48 hours) were injected intraperitoneally into animals with a dose of 10⁷ cells/animal. Subsequently, a second dose of 10⁷ cells/animal was given on day 8. Controls received only PBS. (A) % change in body weight and (B) total MISS score were followed longitudinally between control (n=20 animals) and treatment groups (n=25 animals). Green lines represent mice that survived on day 30 and black lines represent dead animals. (C) Kaplan Meier survival curves were plotted as cumulative data from two independent groups. Cumulative of two independent experiments is shown.