Table 5.

Generalized estimating equation QLU C10D utility decrements (adjusted for non-monotonicities)

Attribute	Levela	Beta (β)	Standard errors	Mean/utility decrement
Time coefficient (α)	(linear)			0.560
Physical functioning	2	− 0.050**	0.021	− 0.089
Physical functioning	3	− 0.091**	0.022	− 0.162
Physical functioning	4	− 0.142**	0.019	− 0.254
Role functioning	2	− 0.002	0.017	− 0.003
Role functioning	3	− 0.058**	0.017	− 0.104
Role functioning	4	− 0.060**	0.015	− 0.107
Social functioning	2	− 0.013	0.015	− 0.023
Social functioning	3	− 0.049**	0.014	− 0.087
Social functioning	4	− 0.049**	0.014	− 0.087
Emotional functioning	2	− 0.007	0.015	− 0.013
Emotional functioning	3	− 0.021*	0.016	− 0.037
Emotional functioning	4	− 0.044**	0.014	− 0.078
Pain	2	− 0.015	0.015	− 0.027
Pain	3	− 0.066**	0.017	− 0.118
Pain	4	− 0.098**	0.015	− 0.175
Fatigue	2	− 0.030**	0.014	− 0.053
Fatigue	3	− 0.034**	0.016	− 0.061
Fatigue	4	− 0.043**	0.014	− 0.076
Sleep disorders	2	0.000	0.000	0.000
Sleep disorders	3	− 0.008	0.014	− 0.015
Sleep disorders	4	− 0.018*	0.012	− 0.033
Lack of appetite	2	− 0.020*	0.014	− 0.036
Lack of appetite	3	− 0.028**	0.013	− 0.050
Lack of appetite	4	− 0.028**	0.013	− 0.050
Nausea	2	− 0.036**	0.015	− 0.064
Nausea	3	− 0.054**	0.012	− 0.096
Nausea	4	− 0.054**	0.012	− 0.096
Bowel problems	2	− 0.024*	0.015	− 0.043
Bowel problems	3	− 0.047**	0.015	− 0.084
Bowel problems	4	− 0.049**	0.013	− 0.087

^aLevel 2 = a little; Level 3 = quite a bit; Level 4 = very much

*p < 0.05; **p < 0.01