Table 2. The included studies, risk of bias tools used, and total scores.

RCT: Randomized clinical trial, AMSTAR: Assessment of multiple systematic reviews, SYRCLE: Systematic review centre for laboratory animal experimentation.

Author & Year	Study Type	Bias Risk Tool	Score
Sánchez-Aguilar et al. 2013 [19]	RCT	Cochrane	7
Naghibi et al. 2016 [22]	RCT	Cochrane	7
Farzanegan et al. 2017 [23]	RCT	Cochrane	7
Govindarajan et al. 2016 [24]	RCT	Cochrane	7
Khokhar et al. 2018 [25]	Cohort	NEWCASTLE - OTTAWA	8
Redelmeier et al. 2019 [26]	Cohort	NEWCASTLE - OTTAWA	7
Li et al. 2020 [27]	Cohort	NEWCASTLE - OTTAWA	7
Mansi et al. 2020 [28]	Cohort	NEWCASTLE - OTTAWA	8
Gruenbaum et al. 2016 [29]	Systematic review	AMSTAR	8
Wang et al. 2014 [30]	Animal clinical trial	SYRCLE	7
Xu et al. 2017 [31]	Animal clinical trial	SYRCLE	8
Wu et al. 2011 [32]	Animal clinical trial	SYRCLE	8
Wu et al. 2012 [20]	Animal clinical trial	SYRCLE	8
Abrahamson et al. 2013 [33]	Animal clinical trial	SYRCLE	7
Xie et al. 2014 [34]	Animal clinical trial	SYRCLE	8
Darwish et al. 2014 [35]	Animal clinical trial	SYRCLE	8
Mountney et al. 2016 [36]	Animal clinical trial	SYRCLE	7
Mountney et al. 2016 [37]	Animal clinical trial	SYRCLE	7