Table 7. Summary of the human studies showing the effect of statins on the overall survival after traumatic brain injury.

TBI: Traumatic brain injury

Study author & year	Type & sample size	Study characteristics	Outcome & conclusion
Mansi et al 2020 [28]	Cohort, 4343	n=4343 TBI, n=172 statin-users, n=4171 nonusers	No statistically significant benefit or harm of statins after TBI
Gruenbaum et al. 2016 [29]	Systematic review, two studies on statins, 112 patients	Systematic search investigated 15 independent pharmacological therapies, 25 studies were selected, two cohort studies on statins were included	Eight of these therapies showed neuroprotective properties, statins showed a reduction in pro-inflammatory mediators and improved functional outcomes after TBI, discontinuation of statins is associated with an increased risk of mortality in the elderly with TBI