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. 2021 Aug 9;6:96. doi: 10.1038/s41541-021-00361-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Representative images from control, prime, and prime-boost vaccinated animals. a H&E: tissue stained with hematoxylin and eosin. Control animals have observable hepatocyte vacuolation (liver), germinal center degeneration characterized by lymphoid depletion and hemorrhage (spleen), and gliosis (brain). No significant lesions are observable in the liver, spleen, or brain of prime or prime-boost vaccinated animals. b IHC: tissue stained with JUNV-specific antibody. Control animals have observable immunolabeling of hepatocytes (liver), germinal centers (spleen), and neurons (brain). No detectable immunolabeling in the liver, spleen, or brain of prime or prime-boost vaccinated animals. Brain images are 10x and spleen/liver are 20x magnification; scale bar 100 μm (brain) and 20 μm (spleen/liver).