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. 2021 Aug 9;11:16142. doi: 10.1038/s41598-021-95403-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Principal component analysis of gene expression levels in the 16 samples, and differential expression analysis. (A, B). Principal component analysis was performed on the gene expression levels for all genes that had a count sum > 0 across all samples. The first two principal components for the collective gene expression in each sample are plotted for samples from (A) straight vessel segments and (B) bifurcations. In both cases, intima samples (circles) are spatially separated form media samples (squares). In addition, sham tissues (solid symbols) are distinguished from tissues taken from ligated animals (hatched symbols). Colored ellipses indicate paired duplicates from 2 different rabbits. (C–F) Gene expression in tissues from ligated and unligated rabbits was compared by RNA-seq. Volcano plots show fold change and p-value for comparisons at BA intima (C), BT intima (D), BA media (E), and BT media (F). Each dot represents one gene, and red dots indicate DEGs, i.e. detectable genes with q-value < 0.05.