. 2021 Aug 9;11:16142. doi: 10.1038/s41598-021-95403-x

Table 1.

Intimal DEGs encoding extracellular products.

DEG	Product class	Bifurcation		Straight vessel
DEG	Product class	Log2(F-C)	q-value	Log2(F-C)	q-value
Up-regulated genes
CHI3L2	Enzyme	11.88	0.0469^a	0.00	1.0000
SERPINA6	Other	10.72	0.0084^a	5.06	0.4320
HBEGF	GF	4.80	0.0014^a	1.08	1.0000
TIMP1	Cytokine	4.52	0.0000^a	3.74	0.0000^a
ADAMTS9	Peptidase	4.08	0.0013^a	2.70	0.1782
SERPINE1	Other	3.91	0.0000^a	2.49	0.0216^a
SEMA3F	Other	3.39	0.0022^a	2.12	0.3327
BMP2	GF	3.35	0.0497^a	0.34	1.0000
IL15	Cytokine	3.11	0.0142^a	1.79	0.6464
PLAT	Peptidase	2.77	0.0261^a	1.35	0.8802
ADAMTS6	Peptidase	2.63	0.0456^a	1.74	0.6622
GLIPR1	Other	1.06	0.5043	2.42	0.0340^a
Down-regulated genes
PTN	Growth factor	− 17.17	0.0000^a	− 7.86	0.2483
PROS1	Other	− 14.76	0.0019^a	− 1.58	1.0000
MFAP5	Other	− 12.86	0.0030^a	− 9.54	0.1498
VIT	Other	− 12.80	0.0030^a	1.44	1.0000
CST6	Other	− 12.76	0.0107^a	− 8.97	0.3702
C1QA	Other	− 12.48	0.0186^a	− 0.78	1.0000
TTR	Transporter	− 12.18	0.0275^a	− 7.27	0.7186
C2	Peptidase	− 11.60	0.0265^a	− 2.14	1.0000
CXCL10	Cytokine	− 11.55	0.0027^a	3.42	0.7338
NID2	Other	− 10.86	0.0056^a	− 0.75	1.0000
C1QTNF7	Other	− 10.64	0.0007^a	− 8.63	0.0029^a
CXCL11	Cytokine	− 10.15	0.0322^a	− 0.88	1.0000
BMP3	Growth factor	− 9.57	0.0045^a	− 0.12	1.0000
HP	Peptidase	− 9.10	0.0080^a	− 1.54	1.0000
C1QC	Other	− 8.76	0.0056^a	− 1.71	1.0000
ITIH2	Other	− 8.61	0.0206^a	1.24	1.0000
IGF1	Growth factor	− 8.54	0.0339^a	0.80	1.0000
PLA2G7	Enzyme	− 8.30	0.0112^a	− 3.68	0.7504
LYPD6	Other	− 7.78	0.0182^a	− 9.65	0.0609
RSPO3	Kinase	− 6.86	0.0664	5.41	0.9693
ANGPTL4	Other	− 6.76	0.0253^a	− 2.53	0.9693
NDP	Growth factor	− 6.71	0.0583	− 10.76	0.0216^a
SPP1	Cytokine	− 5.39	0.0004^a	− 4.13	0.0216^a
IGFBP2	Other	− 5.12	0.0286^a	− 2.92	0.6982
OGN	Growth factor	− 4.91	0.0000^a	− 2.19	0.3549
SERPINF1	Other	− 4.70	0.0322^a	1.87	0.9852
CYTL1	Cytokine	− 4.14	0.0008^a	− 3.74	0.0073^a
LUM	Other	− 4.07	0.2310	− 14.04	0.0007^a
OMD	Other	− 3.91	0.0000^a	− 2.94	0.0073^a
ISG15	Other	− 3.56	0.0024^a	0.01	1.0000
LCAT	Enzyme	− 3.52	0.0417^a	− 1.14	1.0000
ABI3BP	Other	− 3.21	0.0196^a	− 3.57	0.0216^a
CYR61	Other	− 3.12	0.0126^a	− 1.61	0.7504
SELENOP	Other	− 2.83	0.0040^a	− 1.84	0.3549
COL14A1	Other	− 2.82	0.0117^a	− 0.79	1.0000
IGFBP6	Other	− 2.81	0.0042^a	− 0.52	1.000
SAMD9L	Other	− 2.41	0.0483^a	0.92	1.000

All genes whose expression was significantly different between ligated and unligated animals in the intima of bifurcations (BT) or straight vessels (BA) and whose product was classified as extracellular in the Ingenuity Pathway Analysis database are listed.

DEG differentially expressed gene, F-C fold-change.

^aSignificantly different expression between ligated and unligated.