Table 2.
Highly correlated intimal DEGs with extracellular products.
| Intimal gene | # of medial correlates | # of positive correlates | # of negative correlates | Gene product |
|---|---|---|---|---|
| Up-regulated by flow | ||||
| SERPINA6 | 287 | 182 | 105 | Serpin A6 |
| GLIPR1 | 257 | 153 | 104 | Glioma pathogenesis-related protein 1 |
| SERPINE1 | 255 | 152 | 103 | Serpin E1 |
| ADAMTS9 | 235 | 132 | 103 | A disintegrin and metalloprotease with thrombospondin motifs 9 |
| TIMP1 | 224 | 123 | 101 | Tissue inhibitor of metalloprotease 1 |
| IL15 | 219 | 112 | 97 | Interleukin 15 |
| Down-regulated by flow | ||||
| CYTL1 | 283 | 106 | 177 | Cytokine-like protein 1 |
| NDP | 281 | 104 | 171 | Norrin |
| SPP1 | 269 | 89 | 180 | Osteopontin |
| C1QTNF7 | 267 | 104 | 163 | C1q and tumor necrosis factor-related protein 7 |
| LYPD6 | 254 | 84 | 170 | Ly6/PLAUR domain-containing 6 |
| LUM | 251 | 95 | 156 | Lumican |
| CYR61 | 250 | 93 | 157 | Cell communication network factor 1 |
| ABI3BP | 239 | 95 | 144 | ABI family member 3 binding protein |
| CST6 | 233 | 74 | 159 | Cystatin E/M |
| PLA2G7 | 215 | 76 | 139 | Phospholipase A2 group VII |
| OMD | 204 | 100 | 104 | Osteomodulin |
| MFAP5 | 202 | 61 | 141 | Microfibril associated protein 5 |
For each Intimal DEG encoding an extracellular product, the number of medial DEGs whose expression significantly correlated was determined. The intimal DEGs with > 200 medial correlates are listed. The upper portion of the table shows genes that were upregulated by increased flow (at both the BA and BT) and the bottom genes were decreased by flow (at both the BA and BT).