Table 2.
Germline analysis of nCoVmab1 and nCoVmab2.
| mAbs | VH | DH | JH | Identity (VH) | Identity (JH) | VL | JL | Identity (VL) | Identity (JL) |
|---|---|---|---|---|---|---|---|---|---|
| nCoVmab1 | IGHV3 -66*02 | IGHD3 -10*01 | IGHJ 6*02 | 98.95% (282/285 nt) | 93.55% (58/62 nt) | IGLV1 -40*02 | IGLJ 3*02 | 90.97% (262/288 nt) | 97.06% (33/34 nt) |
| nCoV mab2 | IGHV3 -66*02 | IGHD3 -10*01 | IGHJ 6*02 | 98.25% (280/285 nt) | 93.55% (58/62 nt) | IGLV1 -40*01 | IGLJ 3*02 | 98.26% (283/288 nt) | 100.00% (33/34 nt) |
V-(D)-J rearrangement summary for nCoVmab1 and nCoVmab2. Listed data are the top matches for Homo sapiens germline genes corresponding to the V, D, and J of the heavy chain (VH, DH, and JH) and the V and J of the light chain (VL and JL). Nucleotide sequence identities with the top-matched VH and VL genes are also listed.