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. 2021 Aug 9;11:16125. doi: 10.1038/s41598-021-95650-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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NTAPP stimulates the Wnt/β-catenin pathway and enhances hair regrowth in a mouse model. (A) The back skins of 7-week-old female C57BL/6 mice (n = 5–6 per group, three independent experiments) were shaved and treated with NTAPP (4.2 kV) for 1 or 2 min on 7 consecutive days. (B) Gross images of mouse dorsal skin on day 0, 8 and 16 days after the start of NTAPP treatment (top panels); hematoxylin and eosin (H&E) staining of the mouse back skins (lower panels, scale bar = 200 μm). (C–F) Histological analysis of bulb diameter, skin thickness, hair follicle length, and relative hair regrowth area. (G) Western blot analysis of β-catenin, GSK3β, AKT, and cyclin D1 levels in NTAPP-treated mouse skin. (H) A graphical summary of results. All results presented are representative of at least three independent experiments. p values were determined by one-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001 (vs. control). The original uncropped images for g are available in Supplementary Information.