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. 2021 Aug 10;7:64. doi: 10.1038/s41421-021-00300-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — at-SNE analysis of B cells subtypes from all participants and timepoints. b Proportions of the B cell subtypes across participants and timepoints. c The pie plot showing the BCR clone differences across timepoints. The complexity and distribution of clonotypes differed among samples. d The bar plot showing the relative percentage of each isotype by each participant and timepoint. e The circus plots of the rearrangements of the BCR chains split by timepoints. The arc length of each segment corresponds to the relative frequency of each VDJ gene family. Within each plot, pairing VDJ gene segments are represented by colored ribbons. Ribbon width corresponds to frequency of the represented pairing. f The volcano plot showing the DEGs of expanded vs. non-expanded memory B cells and plasma cells at day 14 and day 28 post-vaccination. Genes with greatest fold changes and significant P values were annotated in the plot. g The enriched GO terms of the DEGs in expanded B cells upregulated 28 days post-vaccination.