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. 2021 Aug 10;7:64. doi: 10.1038/s41421-021-00300-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — at-SNE showing expanded TCR clones (n ≥ 2) in the total T cells indicated by timepoints. b Counts of expanded TCR clones in T cell subtypes. c The pie plot showing the TCR clone differences across the different timepoints and individuals. d Heatmap of z-scored mean expression of T cell activation signature (defined as the normalized mean expression of genes in the activation signature in Supplementary Table S4) across T cells from each participants and timepoints. Top, bar plot of total expression of each gene, across all patients. Expression of T cell activation signature shows variability among individuals. e The volcano plot showing the DEGs between CD8⁺ T cells with expanded and unexpanded TCR clones at day 14 post-vaccination. Genes with greatest fold changes and significant P values were annotated in the plot. f The enriched GO terms of the DEGs between T cells with expanded and unexpanded TCR clones at day 14 post-vaccination. P value was derived by a hypergeometric test.