Table 1.
Baseline demographic and clinical characteristics of the study cohort (n = 71).
| Parameters | Pre-Na (n = 25) |
Post-Nb (n = 21) |
Post-Lc (n = 25) |
p-value |
|---|---|---|---|---|
| Age (years) | 33.0 ± 4.10 | 53.48 ± 3.96 | 57.60 ± 4.44 |
a vs b < 0.0001 a vs c < 0.0001 b vs c 0.0019 |
| BMI (kg/m2) | 24.41 ± 4.3 | 27.49 ± 3.97 | 25.08 ± 4.75 |
a vs b 0.008 a vs c 0.462 b vs c 0.072 |
| YSM | – | 4.864 ± 3.028 | 10.92 ± 5.461 | b vs c < 0.0001 |
| BMD at spine (g/cm2) | 1.196 ± 0.07 | 1.122 ± 0.08 | 0.721 ± 0.09 |
a vs b 0.107 a vs c < 0.0001 b vs c < 0.0001 |
| BMD at femoral neck (g/cm2) | 1.01 ± 0.07 | 0.963 ± 0.08 | 0.672 ± 0.13 |
a vs b 0.081 a vs c < 0.0001 b vs c < 0.0001 |
| T-scores spine | 0.05 ± 0.53 | − 0.19 ± 0.79 | − 3.87 ± 0.69 |
a vs b 0.308 a vs c < 0.0001 b vs c < 0.0001 |
| T-scores femoral neck | − 0.25 ± 0.56 | − 0.44 ± 0.64 | − 2.82 ± 0.36 |
a vs b 0.098 a vs c < 0.0001 b vs c < 0.0001 |
| Biochemical and Hormonal Estimations | ||||
| Calcium (mg/dL) | 8.929 ± 0.32 | 9.358 ± 0.32 | 8.529 ± 0.28 |
a vs b 0.019 a vs c 0.143 b vs c 0.311 |
| Phosphorous (mg/dL) | 5.013 ± 0.63 | 5.658 ± 0.66 | 5.115 ± 0.83 |
a vs b 0.069 a vs c 0.657 b vs c 0.071 |
| CRP (mg/L) | 2.898 ± 2.72 | 5.395 ± 4.82 | 4.748 ± 3.88 |
a vs b 0.022 a vs c 0.042 b vs c 0.877 |
| Vitamin D (ng/mL) | 20.36 ± 14.82 | 28.25 ± 16.77 | 31.02 ± 25.21 |
a vs b 0.061 a vs c 0.045 b vs c 0.733 |
| Estradiol (pg/mL) | 167.4 ± 181.9 | 91.71 ± 31.37 | 101.41 ± 90.01 |
a vs b 0.003 a vs c 0.0006 b vs c 0.642 |
Values are represented as Mean ± SD; p value < 0.05 is considered significant and marked in bold.
Abbreviations: Pre-N premenopausal women with normal BMD, Post-N postmenopausal women with normal BMD, Post-L postmenopausal women with low BMD, BMI Body Mass Index, YSM Years since Menopause BMD Bone Mineral Density, CRP C-Reactive Protein.