Table 1.
The baseline characteristics of subjects in discovery and validation cohorts.
| Characteristicsa | Discovery control (n = 63) | Discovery gout (n = 77) | Discovery P valueb | Validation control (n = 25) | Validation gout (n = 23) | Validation P valueb | Total (n = 188) |
|---|---|---|---|---|---|---|---|
| Age, years | 40.0 ± 12.1 | 39.9 ± 12.9 | 0.965 | 38.3 ± 13.6 | 41.9 ± 14.4 | 0.227 | 40.0 ± 12.9 |
| BMI, kg/m2 | 23.5 ± 3.0 | 25.0 ± 2.5 | <0.001 | 22.4 ± 2.3 | 25.8 ± 2.9 | <0.001 | 24.3 ± 2.9 |
| CRP, mmol/L | 2.0 ± 3.2 | 24.5 ± 29.9 | <0.001 | 1.5 ± 2.1 | 21.8 ± 18.5 | <0.001 | 14.5 ± 23.6 |
| eGFR, ml/min | 99.7 ± 15.4 | 90.6 ± 22.8 | 0.01 | 104.7 ± 20.6 | 96.5 ± 20.8 | 0.286 | 95.9 ± 20.8 |
| ESR, mm/h | 8.8 ± 7.5 | 30.4 ± 24.6 | <0.001 | 12.7 ± 11.7 | 32.9 ± 15.4 | <0.001 | 21.9 ± 20.9 |
| SCr, μmol/L | 82.3 ± 12.2 | 95.1 ± 21.2 | <0.001 | 83.7 ± 16.0 | 88.5 ± 22.3 | 0.502 | 88.7 ± 19.0 |
| SUA, μmol/L | 361.4 ± 50.4 | 539.2 ± 118.7 | <0.001 | 350.8 ± 57.8 | 555.2 ± 156.8 | <0.001 | 458.7 ± 136.6 |
| Urea, mmol/L | 5.0 ± 1.1 | 4.8 ± 1.5 | 0.129 | 5.0 ± 1.3 | 4.6 ± 1.7 | 0.149 | 4.9 ± 1.4 |
adata are mean ± s.d; BMI body mass index, CRP C-reactive protein, eGFR estimated glomerular filtration rate, ESR erythrocyte sedimentation rate, SCr serum creatinine, SUA serum uric acid.
bP values were obtained by Wilcoxon rank-sum test.