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. 2021 Aug 9;13:25. doi: 10.1038/s41368-021-00128-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The expression of glutamine after stimulating of cigarette smoke. Glutamine-related gene expression in tongue tissues and RAW cells after CSE stimulation are shown in panels a and b. In the CSE stimulation group, the relative expressions of genes Slc1a5, Slc7a5, and Ogdh were significantly increased. c shows that the expression of glutamine, glutamate, and α-KG in the Raw cells under CSE stimulation were significantly increased. Error bars, SEM. *P < 0.05, **P < 0.01, ***P < 0.001