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. 2021 Aug 9;11:16172. doi: 10.1038/s41598-021-95715-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Absolute differences between regional V_T values for postdose scans (n = 10) estimated with a Logan graphical analysis. Postdose V_T values were obtained using either an arterial metabolite corrected plasma input function based on postdose arterial blood samples (V_T,AIF), an arterial metabolite corrected plasma input function based on baseline arterial blood samples (V_T,bAIF) and an image derived input function based on baseline arterial blood samples (V_T,IDIF).