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Astrocytes play a major role in the neuronal activity-dependent elimination of excitatory synapses. Astrocytes (green) eliminate unwanted excitatory synapses from neurons (blue) by phagocytosing them through Megf10 receptors in adult mouse hippocampus. Neuronal activity selectively increases the Megf10-dependent astrocytic phagocytosis of excitatory synapses, which has important implications for synaptic plasticity and memory formation.
