Table 2.
Host and viral characteristics (mutations) selected for predicting severity of influenza A(H3N2) infection among patients hospitalized for severe acute respiratory infection (SARI) (n = 160), Belgium, Influenza season 2016–2017
| Host model (AIC = 168.6) |
Combined model (AIC = 162.6) |
|||
|---|---|---|---|---|
| Variablea | Odds ratiob | 95% CIb | Odds ratiob | 95% CIb |
| Chronic respiratory condition | 2.16 | [0.93, 4.95] | 2.76 | [1.13, 6.76] |
| Chronic cardiovascular condition | 2.05 | [0.91, 4.64] | 1.96 | [0.83, 4.64] |
| Renal insufficiency | 1.94 | [0.78, 4.64] | 1.75 | [0.68, 4.40] |
| Immunocompromised condition | 3.00 | [1.09, 8.19] | 3.35 | [1.16, 9.76] |
| PA T135C | – | – | 0.12 | [0.01, 0.69] |
| PA A1475G | – | – | 2.55 | [0.49, 13.00] |
| NS A323C | – | – | 3.32 | [0.91, 11.91] |
aThe variables were selected by penalized elastic net regression and fitted as predictors in a logistic regression model
bThe mean adjusted odds ratio’s and accompanying 95% confidence intervals (CI) are based on the results of the logistic regression model