Table 1.
Characteristics and clinical course of the patients
| Patient | Clinical course | Intracranial hemorrhage | White matter hyperintensity | Microbleeds | Siderosis | Alzheimer biomarkers | Corticosteroid treatment | Rankin scale (admission-3 months) |
|---|---|---|---|---|---|---|---|---|
|
Patient 1 70-year-old woman Hypertension |
Balint syndrome in July 2019 (ideational and oculomotor apraxia, echolalia, simultagnosia, visual ataxia, palinopsia), subacute cognitive decline |
- Right parietal lobe in June 2015 - Right frontal lobe in December 2017 - Left parietal lobe in July 2019 |
In the right parietal lobe | Multiple | Bilateral | No sample | Methylprednosolone iv 1 g/24 h for 5 days + prednisone 10 mg/day | 3–3 |
|
Patient 2 73-year-old woman Hypertension, mellitus diabetes |
- PRES and amyloid spells in May 2018 - Balint syndrome in October 2020 (oculomotor and ideational apraxia), aphasia, subacute cognitive decline, headache |
NO | Multifocal | Multiple | Left parietal lobe | Positive | Prednisone 1 mg/kg follow by tapering + prednisone10mg/day | 0–1 |
|
Patient 3 87-year-old man Hypertension, dyslipidemia, antiplatelet treatment, rheumatoid arthritis |
Low level of consciousness, subacute cognitive decline, seizures, and parkinsonism | NO | Multifocal | Multiple (especially parietal lobe) | Bilateral (especially parietal lobe) | Positive | Methylprednosolone iv 1 g/24 h for 5 days + prednisone 10 mg/24 h | 1–5 |
|
Patient 4 72-year-old man Hypertension, dyslipidemia, rheumatic polymyalgia (ANA +) |
- Balint syndrome in September 2018 (ideational and oculomotor apraxia, palinopsia, visual ataxia), subacute cognitive decline - Amyloid spells |
Right parietal and occipital lobe | Multifocal | Multiple (especially parietal lobe) | Bilateral (especially parietal lobe) | Positive | Methylprednosolone iv 1 g/24 h for 5 days + prednisone 10 mg/24 h | 1–1 |
|
Patient 5 69-year-old woman |
- Gerstmann syndrome in December 2018 (strephosymbolia, agraphia, alexia, acalculia), subacute cognitive decline - Amyloid spells |
NO | Multifocal | Multiple (especially parietal lobe) | Left parietal lobe | Positive | Methylprednosolone iv 1 g/24 h for 5 days + prednisone 10 mg/24 h | 1–1 |