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. 2021 Jul 27;9:564991. doi: 10.3389/fped.2021.564991

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Copyright © 2021 Xing, Cheng, Zhang, Cai, Wang, Deng, Xu, Xu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical course and skin hyperpigmentation of the patient. (A) Body temperature over the course of treatment. (B) White blood cell (WBC) count in the peripheral blood. (C) Neutrophil percentage (NEUT%) in the peripheral blood. (D) Serum creatinine (SCr) levels. (E) Skin hyperpigmentation and dark red papule appeared in the upper part of trunk of patient on the fourth day of polymyxin B treatment (March 18, 2019). (F) Skin hyperpigmentation gradually disappeared (January 16, 2020).