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. 2021 Jul 27;9:564991. doi: 10.3389/fped.2021.564991

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Copyright © 2021 Xing, Cheng, Zhang, Cai, Wang, Deng, Xu, Xu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of tigecycline and polymyxin B in cerebrospinal fuid (CSF) of the patient. (A) CSF tigecycline concentrations were measured with Two-Dimensional High-Performance Liquid Chromatography (2D-HPLC) method. (B) CSF polymyxin B levels were determined using high performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Red circle represents the day of ITH polymyxin B treatment.