Table 3.

Efficacy of melarsomine for heartworm adulticide treatment in dogs.

References	n	Setting	Treatment protocol	Efficacya	Time point
Keister et al. (6)	6	EI	Melarsomine 2.5 mg/kg IM once	52%	2 m
	9		Melarsomine 2.5 mg/kg IM, repeated after 24 h	91%	2 m
	6		Melarsomine 2.5 mg/kg IM once; then 30 days later 2 doses of 2.5 mg/kg IM, 24 h apart	99%	3 m
Miller et al. (59)	42	NI	Melarsomine 2.5 mg/kg IM once, repeated after 24 h	76%	4 m
	39	NI	Melarsomine 2.5 mg/kg IM once, repeated after 24 h; treatment course repeated after 4 m	90%	8 m

Time point, number of months from initiation of treatment; EI, experimental infection; NI, natural infection.

^a% worms absent or non-viable at necropsy for experimental infections, % with negative antigen test for natural infections.