Table 5B.

Cardiopulmonary changes during heartworm adulticide treatment in dogs, for control groups from studies of moxidectin and doxycycline.

References	Study protocol	Exercise restriction	Summary findings
Savadelis et al. (31, 53)	EI Untreated controls (n = 8)	Moderate; housed in runs, in pairs	•Cough in 1/8
Paterson et al. (9)	NI 2-dose melarsomine without doxy (n = 15)	Recommended, but many were free-roaming	•One developed hemoptysis on day 9 and required prednisone •One developed tachypnea after the first melarsomine injection
Genchi et al. (52)	NI 3-dose melarsomine without doxy (n = 6)	Not stated	Interstitial lung scores on radiographs, worst possible score 3/3. Echo scores based on pulmonary hypertension, worst possible score 3/3 •Two dogs (33%) progressed radiographically from 0/3 to 1/3 at 12 months •All radiographic scores normal at 12 and 18 months •Two had pulmonary hypertension (1/3) at enrollment and 6 months; 1 developed mild new pulmonary hypertension at 6 months (0.5/3) •All other echo scores normal at all time points

NI, natural infection; EI, experimental infection; echo, echocardiogram/echocardiographic.