Figure 1.

Experimental design

(A) Timeline of the different steps occurring during muscle development in mice. The green arrow represents the normal lifespan of control mice (WT). The phenotype of the three mouse models (Mtm1^−/y, Bin1^mck−/−, Dnm2^SL/+) used in this study is illustrated by the colored arrows with a color gradient ranging from green for non-affected mice, yellow for the onset of myopathy, and red for affected mice. (B) Molecular analyses were performed on different mouse models, Mtm1^−/y, Bin1^mck−/−, Dnm2^SL/+, untreated or treated by different therapeutic approaches (overexpression of BIN1, tamoxifen supplementation, or downregulation of Dnm2 either by genetic cross or by ASO injection). Disease signature refers to the common dysregulated genes in the three mouse models compared to WT littermates, while the therapy signature refers to the common genes rescued following the different treatments.