FIGURE 1.

The cohesin complex and associated proteins. (A) Relevant proteins of the cohesin complex and other chromatin-associated proteins. Besides RNA polymerase II (RNAPII) and classical CdLS-related proteins, selected NIPBL-BRD4 common interactors, like other cohesin-related proteins and Mediator (see Figure 3), have been depicted. (B) Proteins in (A), together with additional factors associated with a CdLS-like phenotype, are classified as cohesin-related and/or CdLS-related. (C) Interactome of the additional factors associated with a CdLS-like phenotype (blue) with BRD4 (green) occupying a central position. Dashed lines indicate putative ways of indirect association with BRD4 through the proteins indicated in pink or the cohesin complex (red). Diagram was derived from an esyN tool (http://www.esyn.org/) representation based on BioGRID data.