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. 2021 Jul 27;8:709232. doi: 10.3389/fmolb.2021.709232

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Copyright © 2021 García-Gutiérrez and García-Domínguez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NIPBL and BRD4 interactome. (A) Venn diagram indicating the overlap of NIPBL and BRD4 interactors. Fold-enrichment of common interactors and its associated p-value from the hypergeometric distribution was obtained at (https://systems.crump.ucla.edu/hypergeometric/index.php), assuming a total proteome of at least 100,000 different proteins. Data were obtained from BioGRID (https://wiki.thebiogrid.org/doku.php/tools). Venn diagrams were constructed with the Venny 2.1 tool (https://bioinfogp.cnb.csic.es/tools/venny/) and depicted with Venn Diagram Maker at (https://www.meta-chart.com/venn). (B) Common NIPBL-BRD4 interactome with NIPBL occupying a central position (red). BRD4 is indicated in green, Mediator proteins in purple and cohesin-related proteins in light blue. Data and representation were derived from BioGRID. (C) Gene Ontology (GO) analysis of common interactors was performed with the DAVID tool at (https://david.ncifcrf.gov/tools.jsp). n, number of genes in each category.