Table 3.
Clinically relevant annotations enriched with genes interrupted by gentamicin (partial data).
GO ID | GO Term | Adjusted p-value∗ | Associated genes found |
---|---|---|---|
C0023264 | Leigh syndrome | 9.3E-04 | DLAT, DLD, NDUFA10, NDUFA12, NDUFA2, NDUFA9, NDUFS4, NDUFS8, PDHA1, SDHA |
C0751651 | Mitochondrial diseases | 1.7E-02 | DLAT, DLD, NDUFA10, NDUFA12, NDUFA2, NDUFA9, NDUFB9, NDUFS1, NDUFS4, NDUFS6, NDUFS8, NDUFV1, NDUFV2, PDHA1, SDHA, SDHAF1, SDHD, SUCLA2, SUCLG1 |
C1838979 | Mitochondrial complex I deficiency | 2.0E-01 | NDUFB9, NDUFS1, NDUFS4, NDUFS6, NDUFV1, NDUFV2 |
CN043648 | Nonsyndromic hearing loss and deafness | 1.0E+00 | CLPP, MYH9, RDX |
C0236038 | Hereditary hearing loss and deafness | 1.0E+00 | CLPP, DLAT, DLD, MYH9, NDUFA10, NDUFA12, NDUFA2, NDUFA9, NDUFB9, NDUFS1, NDUFS4, NDUFS6, NDUFS8, NDUFV1, NDUFV2, NF2, PDHA1, RDX, SDHA, SDHAF1, SDHD, SUCLA2, SUCLG1 |
The raw p-values were adjusted using the Bonferroni step down method.