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. 2021 Jul 27;12:697329. doi: 10.3389/fimmu.2021.697329

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Copyright © 2021 Constant, Barthelemy, Bolloré, Tuaillon, Gosselet, Chable-Bessia, Merida, Muriaux, Van de Perre, Salinas and Simonin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of main SARS-CoV-2 cell receptors in our cell models (A) ACE-2 mRNA expression in astrocytes, pericytes, BBB model and endothelial cells in comparison to Vero E6 cells (highly permissive to SARS-CoV-2 infection). (B) No detectable expression of ACE-2 protein by western blot in endothelial and pericytes cells contrary to Vero E6 cells. (C) TCID50 measurements of SARS-CoV-2 in CECs at 2 dpi after treatment with anti-ACE-2 antibody. TCID50 measure results are expressed as mean ± SEM. (D, E) Respectively TMPRSS2 and CTSL mRNA expression in BBB model, pericytes and endothelial cells in comparison to Vero E6 cells.