TABLE 1.

Phenotypes of Papillomavirus E2 Mutations that Affect Brd4 Binding.

Domain	Virus	Mutation	Brd4-dependent transcription	Brd4 CTM binding	Brd4 pNPS binding	Transient replication	E1 binding	Extra-chromosomal replication	References
WT		WT	+++	+++	+++	+++	+++	+++
Transactivation domain	BPV1	R37K	+++			+++,+++	++		(Brokaw et al., 1996; Zheng et al., 2005)
	BPV1	R37A	+,−,++	+		++,+,+++	+++		(Abroi et al., 1996; Abroi et al., 2004; Baxter and McBride, 2005; Baxter et al., 2005)
	CRPV	R37K	+++	++		+++			(Jeckel et al., 2002; Senechal et al., 2007)
	CRPV	R37A	+	+/−		+			(Jeckel et al., 2002; Senechal et al., 2007)
	HPV11	R37K	+	−					(Cooper et al., 1998; Senechal et al., 2007)
	HPV11	R37A	+						Cooper et al. (1998)
	HPV16	R37A	−	+/−		+,+	+++		(Sakai et al., 1996; Schweiger et al., 2006; Wang et al., 2013; Gauson et al., 2015)
	HPV31	R37K	−	+		+++		+,+++	(Stubenrauch et al., 1998; Senechal et al., 2007; Sakakibara et al., 2013)
	HPV18	R41A*		+/−		++			McKinney et al. (2016)
	BPV1	I73N	−			+++			(Ferguson and Botchan, 1996)
	BPV1	I73L	+			+++,+++	+++		Brokaw et al. (1996)
	BPV1	I73A	++,−	+		++,+++	+++		(Baxter and McBride, 2005; Baxter et al., 2005)
	CRPV	I73L	+	++		++			(Jeckel et al., 2002; Senechal et al., 2007)
	HPV16	I73A	−	−		+++, +	+++	−	(Sakai et al., 1996; Schweiger et al., 2006; Wang et al., 2013; Gauson et al., 2015)
	HPV31	I73L	−	−		+++		+++,+++	(Stubenrauch et al., 1998; Senechal et al., 2007; Sakakibara et al., 2013)
	HPV31	I73A						+++	Gauson et al. (2015)
	HPV18	I77A*		+/−		++			McKinney et al. (2016)
DNA binding domain	HPV16	K299L			+++				Wu et al. (2016)
		R302L			+/−				Wu et al. (2016)
		R304L			+++				Wu et al. (2016)
		K306N			−				Wu et al. (2016)
		K307D			+				Wu et al. (2016)
	HPV18	R307N, K308D			−				Wu et al. (2016)