Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 27;12:671057. doi: 10.3389/fgene.2021.671057

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Barefoot, Loyfer, Kiliti, McDeed, Kaplan and Wellstein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Tissue-of-origin deconvolution analysis. CfDNA is a mixture of fragments released from healthy and diseased cells in different tissue types throughout the human body into the circulation. DNA methylation is highly cell-type specific and can be used to identify the cellular origins of cfDNA at specific markers. Tissue-of-origin (TOO) analysis traces cfDNA molecules back to the tissues and cell types they originated from and use changing tissue proportions to reveal altered tissue homeostasis in diseased states or during therapy.