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. 2021 Jul 20;297(2):100982. doi: 10.1016/j.jbc.2021.100982

Figure 1.

Figure 1

Model of NOX2 assembly sequence. The cytochrome b558 that consists of the membrane-anchored gp91 in complex with p22 is shown. Binding of p47 followed by p40 and p67 to the cytochrome b558 results in the formation of the NOX2 phox complex. Step 1: amphipathic arachidonic acid (AA) disables the autoinhibitory function of the “adaptor” protein p47 to make it bind to cytochrome b558 (18), which in turn recruits p40 and p67 onto cytochrome b558 to produce the NOX2 phox complex (19). Step 2: the binding of the active wt Rac to the NOX2 phox complex generates the O2−-producing active NOX2 complex. NOX2, NADPH oxidase 2.