Table 2.

PAI application of stroke in Mouse.

Year	System	Wavelength (nm)	Ultrasound (MHz)	Resolution	Stroke type	Induction	Refs.
2020	PAIa+ PAM + MRI	532, 680 - 950	5, 50	200 μm; 10 μm	Ischemic, hemorrhage	Photothrombosis and MCAO; silicone-coated monofilament	[82]
2019	PAT	532	5	A:1.62 mm	Stroke	Berberine	[83]
				L:180 um
2018	PAM	532, 558	35	–	Ischemic	MCAO with filament	[57]
2018	MSOTb	–	–	–	Ischemic	565 nm LED	[66]
2018	MSOTb+MRI	680−980	5	–	Ischemic	tMCAO	[84,85]
2017	OR-PAM	532	50	A: ∼15 μm	Mini stroke	Phenylephrine	[68]
				L: ∼3 μm
2017	ECoG + fPAM	808, 880	50	A:32 mm	Ischemic	Photothrombotic MACOc	[71]
				L:61 um
2017	PAT	760, 840	5	A: 1 mm	Hemorrhage	Collagenase	[86]
				L: 120 μm
2017	PAT	532, 750, 875	5	L: 180 um	Hemorrhage	Collagenase	[87]
2016	PAM	532, 559	–	–	Ischemic	Photothrombotic occlusion	[67]
2014	MSOTb	710, 850	–	–	Ischemic	MCAO	[65,88]
2013	ECoG + fPAM	560, 570	–	L: 65 μm	Ischemic	Photothrombotic strokec	[89]
2011	OR-PAM	563, 570	50	L: 2.14 μm	Ischemic	tMCAO	[90]

PAI, photoacoustic imaging; PAM, photoacoustic microscopy; OR-PAM, optical-resolution photoacoustic microscopy; PAT, photoacoustic tomography; MRI, magnetic resonance imaging; MSOT, Multispectral optoacoustic tomography; ECoG-fPAM, electrocorticography functional photoacoustic microscopy; MCAO, middle cerebral artery occlusion; tMCAO, transient middle cerebral artery occlusion; L: lateral resolution; A: axial resolution Commercial equipment:

^aNexus 128 scanner, Endra Inc., Ann Arbor, MI.

^bMSOT, iThera Medical Inc., Munich, Germany.

^cExperiments in rats.