Fig. 2.
The antiviral activities of lycorine against other alphaviruses. A–C Dose-dependent inhibition of SINV, SFV and VEEV infection by lycorine. Vero cells infected with different alphaviruses at an MOI of 0.01 were treated with increasing concentrations of lycorine. The supernatants were harvested at 12 hpi for SINV and at 24 hpi for SFV and VEEV. Viral titers were determined by plaque assay. The EC50 are displayed at the lower left for each virus. The dashed lines in panels A–C represent the limit of detection. Two independent experiments were performed in triplicate. Data represent the mean ± standard deviation (SD) of the triplicate measurements in a representative experiment.