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. 2021 Jul 26;22(4):1059. doi: 10.3892/etm.2021.10493

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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miR-139-5p overexpression reduces LPS-induced apoptosis by targeting ROCK1 in NHBEs. (A) Proportion of apoptotic cells among transfected NHBEs was determined using flow cytometry. (B) Expression levels of Bax, Bcl-2, cleaved caspase-3 and caspase-3 in the treated NHBEs were determined using western blotting (left, representative blots; right, densitometry analysis). Data are presented as the mean ± standard deviation. ^***P<0.001 vs. control; ^###P<0.001 vs. miR-NC; ^ΔP<0.01 and ^ΔΔΔP<0.001 vs. miR-139-5p mimics + Vector. NHBEs, normal human bronchial epithelial cells; ROCK1, Rho-associated kinase 1; miR, microRNA; LPS, lipopolysaccharide; NC, negative control; Ov, overexpression.