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High frequency RBD mutations that improve ACE2 binding
| ACE2 residue | SARS-CoV-2 RBD residue |
|---|---|
| S19 | A475, G476 |
| Q24 | A475, G476, N487 |
| T27 | F456, Y473, A475, Y489 |
| F28 | Y489 |
| D30 | K417, L455, F456 |
| K31 | L455, F456, Y480, E484, F490, Q493 |
| H34 | Y453, L455, Q493 |
| E35 | Q493 |
| E37 | Y505 |
| D38 | Y449, G496, Q498 |
| Y41 | T500, N501, Q498 |
| Q42 | G446, Y449, Q498 |
| L45 | Q498, T500 |
| L79 | F486 |
| M82 | F486 |
| Y83 | F486, N487, Y489 |
| N330 | T500 |
| K353 | G496, N501, G502, Y505 |
| G354 | Y502, Y505 |
| D355 | T500, G502 |
| R357 | T500 |
| R393 | Y505 |
