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. 2021 Aug 10;16:76. doi: 10.1186/s13020-021-00488-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — HGWD attenuated mechanical allodynia, thermal hyperalgesia, and morphological changes of DRG in PIPN rats. a Protocol showing drug administration and behavioral tests in the rat model. b Mechanical withdrawal threshold was measured by the von Frey test. c Thermal withdrawal threshold was evaluated by the hot plate test. d Time course effect of HGWD on body weight of rats. e DRG sections were stained by Nissl and observed by light micrographs (80 ×). The occurrence of eccentric nucleoli (red arrow) and multinucleolated neurons (red arrowhead) were analyzed. Histograms show the effect of HGWD on the incidence of nuclear and nucleolar pathological features. ^*P < 0.05, ^**P < 0.01 ^***P < 0.001, vs. vehicle group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, vs. PIPN group, n = 8 rats/group