Fig. 9.

HGWD regulated the expression of TLR4/NF-κB and PI3K/Akt-Nrf2 pathways in PTX-treated rats. a HGWD downregulated TLR4/NF-κB signaling. b HGWD upregulated the expression of PI3K and phosphorylated Akt proteins. c HGWD activated Nrf2-OH-1 pathway. Levels of TLR4, MyD88, IKKα, NF- κB, p-NF-κB, PI3K, p-AKT, Nrf2, Keap1, HO-1, and β-tubulin from DRG tissues were determined by western blot analysis. Data are expressed as means ± SEM. ^*P < 0.05, ^**P < 0.01 ^***P < 0.001, vs. vehicle group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, vs. PIPN group