Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 10;16:53. doi: 10.1186/s13024-021-00475-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Genome-wide effects of the SRSF1 depletion in human healthy and C9ORF72-ALS neurons. A Multidimensional scale analysis of the WCT and CyT transcriptomes for healthy (blue) and C9-ALS (red) lines of patient-derived neurons treated with C-RNAi or SRSF1-RNAi (Δ). B Volcano plots representing the genome-wide distribution of differentially-expressed transcripts according to p-values and fold changes for C9-disease (H_C-RNAi versus C9_C-RNAi), C9-treated (C9_C-RNAi versus C9_SRSF1-RNAi) and H-treated (H_C-RNAi versus H_SRSF1-RNAi) neuron groups. NS: non-significant; FC: fold changes < 2; P: p-values > 0.05; P & FC: significant p-values (< 0.05) & fold changes (> 2). Red labels indicate the numbers of significantly down- or up- regulated annotated transcripts. C, D Venn diagrams representing differentially-expressed transcripts at WCT level for C9-disease, C9-treated and H-treated groups. E Bar charts representing enrichment scores for the 12 top biological processes identified via functional annotation clustering for the C9-disease group (1470 protein coding DEGs). The enrichment scores corresponding to the 12 altered biological pathways are also reported for the C9-treated (254 protein-coding DEGs) and H-treated groups (470 protein-coding DEGs). The GO terms are provided with gene IDs and statistics in Table S6. Numbers at bar extremities indicate the numbers of genes altered in each pathways. The neuroprotective depletion of SRSF1 mitigates most of the disease-altered pathways