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. 2021 Aug 5;15:3425–3441. doi: 10.2147/DDDT.S315060

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© 2021 Zhang et al.

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Network construction and targets or active compounds prediction. (A) CSS-targets-MDD network. Blue nodes stand for targets of CSS, green nodes stand for targets of MDD, and orange nodes represent the overlapped targets between CSS and MDD. Lines represent interactions between two nodes. (B) Compound-MDD target network. Orange circles stand for the overlapped targets, and blue rectangles stand for potential active compounds. (C) Degree of potential compounds. (D) PPI network of the shared targets. Orange nodes represent the overlapped targets. Pink lines represent the connections based on experimental evidence; blue lines represent the relationships which are predicted from curated databases. (E) Degree of hub targets (Top 10) in the PPI network.