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. 2021 Jun 11;112(8):3018–3028. doi: 10.1111/cas.14971

FIGURE 4.

FIGURE 4

Coexpression of signal regulatory protein α (SIRPα) and programmed cell death‐ligand 1 (PD‐L1) was prognostically significant in esophageal squamous cell carcinoma (ESCC). A, B, Representative images of SIRPα (A) and PD‐L1 (B) in a surgically resected specimen from one patient with ESCC. The images represent a single area of one specimen. Scale bar = 100 μm. C, D, Kaplan‐Meier curves showing overall survival (C) and disease‐free survival (D) of patients with ESCC according to the SIRPα and PD‐L1 expression patterns. Red, green, blue, and brown curves represent SIRPα–/PD‐L1– (n = 33), SIRPα–/PD‐L1+ (n = 14), SIRPα+/PD‐L1– (n = 31), and SIRPα+/PD‐L1+ (n = 53), respectively. Statistical analysis was undertaken using the log‐rank test. E, Schematic model of combination therapy targeting both the CD47‐SIRPα and PD‐1‐PD‐L1 axes