TABLE 2.
Univariable and multivariable Cox regression analysis for disease‐free survival (DFS) and overall survival (OS) among patients with esophageal squamous cell carcinoma (n = 131)
| Factor | DFS | OS | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariable analysis | Multivariable analysis | Univariable analysis | Multivariable analysis | ||||||||||
| HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | ||
| Age, years | 0.991 | 0.962‐1.022 | .6000 | – | – | – | 0.995 | 0.959‐1.032 | .790 | – | – | – | |
| Sex | Male | 0.667 | 0.347‐1.278 | .2400 | – | – | – | 1.027 | 0.458‐2.302 | .940 | – | – | – |
| Tumor location | Ce and Ut | 1.508 | 0.908‐2.507 | .1100 | – | – | – | 1.171 | 0.640‐2.143 | .610 | – | – | – |
| Histopathology | Poorly differentiated | 1.487 | 0.734‐3.012 | .2900 | – | – | – | 1.754 | 0.816‐3.772 | .170 | – | – | – |
| pStage | II‐III | 2.587 | 1.378‐4.856 | .0012 | 2.811 | 1.475‐5.357 | <.001 | 1.909 | 0.948‐3.844 | .055 | 2.039 | 0.994‐4.183 | .0400 |
| Effect of preoperative treatment | Grade 2‐3 | 0.360 | 0.164‐0.790 | .0038 | 0.281 | 0.127‐0.622 | <.001 | 0.334 | 0.131‐0.847 | .008 | 0.265 | 0.102‐0.683 | .0013 |
| SIRPα expression | High | 1.775 | 1.017‐3.096 | .0350 | 1.600 | 0.907‐2.821 | .090 | 2.056 | 1.045‐4.042 | .027 | 1.988 | 0.998‐3.959 | .0400 |
| PD‐L1 expression | Positive | 1.425 | 0.867‐2.343 | .1500 | – | – | – | 1.151 | 0.649‐2.043 | .620 | – | – | – |
| SIRPα/PD‐L1 | Coexpression | 1.624 | 0.992‐2.658 | .0550 | – | – | – | 1.627 | 0.916‐2.887 | .090 | – | – | – |
Abbreviations: Ce, cervical esophagus; CI, confidence interval; HR, hazard ratio; PD‐L1, programmed cell death‐ligand 1; pStage, pathological stage; SIRPα, signal regulatory protein alpha; Ut, upper thoracic esophagus; –, not included in analysis.