TABLE 3.
Univariable and multivariable analysis of the relationship between signal regulatory protein alpha (SIRPα) expression and other clinicopathological factors in patients with esophageal squamous cell carcinoma (n = 131)
| Factor | Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | ||
| Age, years | 1.009 | 0.967‐1.052 | .6600 | – | – | – | |
| Sex | Male | 1.050 | 0.382‐2.880 | .9200 | – | – | – |
| Tumor location | Ce and Ut | 0.820 | 0.382‐1.761 | .6100 | – | – | – |
| Histopathology | Poorly differentiated | 1.135 | 0.363‐3.543 | .8200 | – | – | – |
| pT | T2‐4 | 3.339 | 1.559‐7.147 | .0017 | 3.555 | 1.218‐10.37 | .0160 |
| pN | N1‐3 | 1.032 | 0.491‐2.167 | .9300 | – | – | – |
| Preoperative treatment | Yes | 1.500 | 0.678‐3.313 | .3100 | – | – | – |
| Effect of preoperative treatment | Grade 2‐3 | 1.523 | 0.612‐3.790 | .3500 | – | – | – |
| CD80 | Number of positive cells/HPF | 1.008 | 1.002‐1.015 | .0045 | 1.004 | 0.996‐1.013 | .2100 |
| CD163 | Number of positive cells/HPF | 1.019 | 1.011‐1.027 | <.001 | 1.015 | 1.005‐1.025 | <.0010 |
| CD8 | Number of positive cells/HPF | 0.994 | 0.987‐1.002 | .1500 | 0.983 | 0.971‐0.995 | .0017 |
| PD‐L1 | Positive | 4.029 | 1.872‐8.671 | <.001 | 3.766 | 1.148‐12.35 | .0240 |
Abbreviations: Ce, cervical esophagus; CI, confidence interval; HPF, high‐powered field; OR, odds ratio; PD‐L1, programmed cell death‐ligand 1; pN, pathological lymph node metastasis; pT, pathological depth of tumor invasion; Ut, upper thoracic esophagus; –, not included in analysis.