TABLE 2.
Multivariate analyses in OS of pN0 patients with gastric cancer
| Prognostic factors | Total (n = 4607) | pT1 (n = 1670) | pT2 (n = 939) | pT3 (n = 862) | pT4 (n = 1136) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | HR | 95% CI | P‐value | HR | 95% CI | P‐value | HR | 95% CI | P‐value | |
| Age at diagnosis (y) | |||||||||||||||
| Younger (≤35) | 1 | – | 1 | – | 1 | ||||||||||
| Middle‐aged (36‐65) | 1.293 | 0.570‐2.933 | .539 | 1.339 | 0.180‐9.942 | .775 | 0.961 | 0.383‐2.413 | .932 | ||||||
| Older (≥66) | 2.236 | 0.974‐5.131 | .058 | 4.140 | 0.548‐31.271 | .169 | 1.299 | 0.500‐3.371 | .591 | ||||||
| Gender | |||||||||||||||
| Male | 1 | 1 | 1 | 1 | 1 | ||||||||||
| Female | 0.973 | 0.745‐1.270 | .838 | 0.363 | 0.077‐1.706 | .199 | 0.937 | 0.456‐1.925 | .858 | 0.914 | 0.514‐1.626 | .759 | 1.156 | 0.815‐1.640 | .415 |
| Year at diagnosis | |||||||||||||||
| 2000‐2004 | 1 | 1 | – | 1 | – | ||||||||||
| 2005‐2009 | 1.349 | 0.684‐2.663 | .388 | 0.984 | 0.166‐5.817 | .985 | 0.674 | 0.299‐1.517 | .341 | ||||||
| 2010‐2013 | 1.502 | 0.764‐2.953 | .238 | 0.698 | 0.101‐4.800 | .698 | 0.488 | 0.199‐1.197 | .488 | ||||||
| 2014‐2017 | 1.088 | 0.536‐1.376 | .815 | 0.352 | 0.031‐4.022 | .352 | |||||||||
| Type of gastrectomy | |||||||||||||||
| Proximal | 1 | 1 | 1 | 1 | 1 | ||||||||||
| Distal | 0.632 | 0.469‐0.853 | .003 | 0.787 | 0.247‐2.508 | .685 | 0.449 | 0.249‐0.811 | .008 | 0.633 | 0.341‐1.175 | .147 | 0.757 | 0.467‐1.126 | .257 |
| Total | 1.268 | 0.926‐1.736 | .139 | – | 0.500 | 0.22‐1.135 | .098 | 1.366 | 0.768‐2.431 | .288 | 1.760 | 1.080‐2.869 | .023 | ||
| Vascular invasion | |||||||||||||||
| Yes | 1 | 1 | 1 | 1 | 1 | ||||||||||
| No | 0.992 | 0.760‐1.293 | .951 | 0.211 | 0.049‐0.915 | .038 | 0.874 | 0.450‐1.698 | .691 | 0.974 | 0.575‐1.650 | .922 | 1.111 | 0.775‐1.591 | .568 |
| Nerve invasion | |||||||||||||||
| Yes | 1 | – | 1 | 1 | 1 | ||||||||||
| No | 0.614 | 0.455‐0.828 | .001 | 0.753 | 0.412‐1.377 | .357 | 0.642 | 0.363‐1.133 | .126 | 0.621 | 0.391‐0.986 | .043 | |||
| Adjuvant therapy | |||||||||||||||
| Yes | 1 | 1 | 1 | 1 | 1 | ||||||||||
| No | 1.105 | 0.833‐1.465 | .489 | 3.312 | 1.050‐10.449 | .041 | 1.051 | 0.601‐1.836 | .862 | 1.136 | 0.648‐1.990 | .656 | 1.488 | 0.977‐2.265 | .064 |
| ELNs | |||||||||||||||
| ELNs ≤ 15 | 1 | 1 | 1 | 1 | 1 | ||||||||||
| 16 ≤ ELNs ≤ 29 | 0.985 | 0.697‐1.393 | .933 | 1.992 | 0.596‐6.663 | .264 | 1.634 | 0.686‐3.889 | .267 | 0.576 | 0.289‐1.148 | .117 | 0.879 | 0.534‐1.447 | .613 |
| ELNs≥30 | 0.820 | 0.560‐1.199 | .306 | 0.609 | 0.060‐6.617 | .675 | 2.092 | 0.798‐5.482 | .133 | 0.397 | 0.182‐0.866 | .020 | 0.772 | 0.453‐1.316 | .342 |
| Pathologic T stage | |||||||||||||||
| T1 + Tis | 1 | – | |||||||||||||
| T2 | 3.384 | 1.867‐6.135 | <.001 | ||||||||||||
| T3 | 4.119 | 2.254‐7.528 | <.001 | ||||||||||||
| T4 | 8.644 | 4.829‐15.473 | <.001 | ||||||||||||
Adjusted factors: age, gender, year at diagnosis, type of gastrectomy, vascular invasion, nerve invasion, adjuvant therapy, ELNs, pathologic T stage.