FIGURE 1.

Mature sterol regulatory element‐binding protein 1 (mSREBP1) and symmetric dimethyl arginine (SDMA) overexpressed and positively correlated with Ser473‐phosphorylated protein kinase B (AKT‐473P) in human lung adenocarcinoma tissues. A, B, Representative histopathologic sections of human adenocarcinoma and adjacent non‐tumor lung tissues stained with (A) AKT‐473P and (B) mSREBP1‐SDMA Abs. Scale bar = 50 μm. C, D, Semiquantitative analyses of (C) AKT‐473P and (D) mSREBP1‐SDMA staining scores in human adenocarcinoma and adjacent nontumor lung tissues. E, Kaplan‐Meier analysis of overall survival depending on the AKT‐473P level in lung adenocarcinoma tissues, and the mortality rate and median survival of low and high AKT‐473P expression groups were 33.3% (17/51) and 76.5% (39/51), and 83 and 23 mo, respectively. F, Kaplan‐Meier analysis of overall survival depending on the mSREBP1‐SDMA level in lung adenocarcinoma tissues, and the mortality rate and median survival of low and high mSREBP1‐SDMA expression groups were 38.3% (18/47) and 69.1% (38/55), and 83 and 31 mo, respectively. G, Kaplan‐Meier analysis of overall survival depending on the AKT‐473P and mSREBP1‐SDMA coexpression status. Mortality rate and median survival of the four groups were: 31.2% (5/16) and 66 mo of low AKT‐473P and high mSREBP1‐SDMA expression group; 34.3% (12/35) and 83 mo of low AKT‐473P and low mSREBP1‐SDMA expression group; 50.0% (6/12) and 62 mo of high AKT‐473P and low mSREBP1‐SDMA expression group; and 84.6% (33/39) and 21 mo of AKT‐473P and mSREBP1‐SDMA co‐high expression group, respectively